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FRIESS, S. S. Bull. 13, 41 (1963). FRIESS, S. : Toxicol. appl. Pharmac. 7, 373 (1965). FRIESS, S. , CHANLEY, J. , MEZETTI, R: Biochem. 14, 1237 (1965). FRIESS, S. , CHANLEY, J. : Biochern. 16, 1617 (1967). FRIESS, S. , CHANLEY, J. : Toxicon 6,81 (19681). : Naturwissenschaften 55,83 (1968). HABERMEHL, G. : Liebigs Annln Chern. 731, 53 (1970). NIGRELLI, R E: Zoologica 37,89 (1952). : Ann. Y. Acad. Sci. 90, 884 (1960). : J. Am. chern. Soc. 91, 4918 (1969). S. , DUFFIELD, A. : Tetrahedron, 23, 761 (1967').

Dies ist nur ein Spezialfall der Freisetzung pharmakologisch aktiver Substanzen durch Melittin. Eine Schadigung auch anderer Kalium-Barrieren konnte auch fur weitere Effekte mitverantwortlich sein. Ebenso wie Erythrocyten werden auch Mastzellen, die Histamin und Serotonin enthalten, durch Melittin zerstort; in gleicher Weise wird aueh Serotonin aus Thromboeyten freigesetzt. Die Kontraktion der glatten Muskulatur beruht sieher nieht nur auf der Freisetzung der genannten biogenen Amine. Die Melittin-Kontraktion unterseheidet sich von der des Histamins eharakteristisch dureh das langsamere Einsetzen und die langere Dauer.

J. 117, 543 (1970). GOAD, L. , SMITH, A. : Proc. Roy. Soc. (London), Ser. B 180, 223 (1972). 46 Echinodermata (Stachelhauter) SHEIKH, Y. : J. Arner. chern. Soc. 94, 3278 (1972). , SMI1H, D. S. : Nature (London) 233, 209 (1971). : Tetrahedron Letters (London) 1601 (1972). , SCHEUER, P. : Tetrahedron (London) 24, 5831 (1968). : Tetrahedron Letters (London) 2935, (1972). SMI1H, A, GOAD, L. : Biochern. J. 123, 671 (197,1). , GOAD, L. : Biochern. 135, 443 (1973). PREUSSER, H. : Toxicon 13, 285 (1975).

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