By T. L. J. Boehm

l Tumor transformation produces various antigenic changes ), fairly 2 one of the glycoconjugates, sugars associated with one another, to lipids and to proteins , 3). Many blood crew antigens are pointed out as glycoconjugates; they contain the four ABO(H) , MNT, Lewis, Ii and P antigens ). those determinants are rather invaluable given that they are often understood when it comes to their serology, chemical constitution and biochemical genetics4-7). Their particular services should not good understood; how­ ever, their place as terminal or penultimate sugars may possibly assign them a unique position lO as protecting or informational moleculesS- ). more often than not, those antigens, both 4lO defined on erythrocytes ), persist unchanged through the life of the indi­ vidual, yet they're vulnerable to adjustments within the presence of convinced hematopoietic illnesses and strong tissue tumors, basically carcinomas. A assessment of eleven this subject was once released through one in every of us in 1980 ). New information has amassed speedily seeing that then, quite within the components of structural research, biochemical genetics, and immunologic and tumor marker relationships. the aim of this evaluate is to supply an replace of development discovered in those components. different stories with emphasis 12 l5 on particular parts also are to be had - ). present and potential experimental reviews may be of use in regard to the subsequent questions: 1.

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