By Armand Marie Leroi
Stepping without difficulty from fable to state of the art technological know-how, Mutants offers a super narrative account of our genetic code and the appealing humans whose our bodies have printed it—a French convent lady who discovered herself altering intercourse at puberty; youngsters who, echoing Homer’s Cyclops, are born with a unmarried eye in the midst of their foreheads; a village of long-lived Croatian dwarves; one kin, whose our bodies have been solely coated with hair, was once stored on the Burmese royal court docket for 4 generations and gave Darwin certainly one of his keenest insights into heredity. This based, humane, and interesting e-book “captures what we all know of the improvement of what makes us human” (Nature).
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Additional resources for Mutants: On Genetic Variety and the Human Body
Forty years ago genetic doctrine was rocked by the recognition that a human cell has 46 chromosomes, not 48. The past 10 years mark the discovery of entirely new inheritance patterns such as mitochondrial inheritance, imprinting, and dynamic mutations. The family pedigree will undoubtedly serve as a template for new discoveries in gene action and interaction as the practice of genomic medicine unfolds. REFERENCES American College of Medical Genetics/American Society of Human Genetics (ACMG/ASHG) Huntington Disease Genetic Testing Working Group (1998).
Height and skin color are good examples of conditions in which multiple genes and the environment are involved in phenotypic expression. Many isolated birth defects such as pyeloric stenosis, clubfoot, scoliosis, and neural tube defects are believed to have a multifactorial etiology. Common illnesses in adults, such as diabetes, asthma, hypertension, epilepsy, and mental disorders are also thought to have multiple genetic and environmental factors at the root of their expression. Pedigrees documenting conditions that have a multifactorial or polygenic etiology usually have no other, or few, affected family members (Fig.
Feinberg, 1998). edu. Classic examples of imprinting are Prader–Willi syndrome and Angelman syndrome. Both of these distinctly different genetic conditions have alterations in the same genetic region—a tiny segment of the long arm (q arm) of chromosome 15 (15q11-q13). If the altered region is inherited from the father, the child (son or daughter) has Prader–Willi syndrome. The hallmark features of Prader–Willi syn- NONTRADITIONAL INHERITANCE PATTERNS 33 drome are hypotonia in childhood, almond-shaped eyes, small hands and feet, obesity and overeating, and a mean IQ of 50.