By J.M.C. Connell, A.F. Dominiczak, F Soubrier

Molecular Genetics of high blood pressure is likely one of the first books to consolidate the present wisdom of this increasing learn quarter. The e-book considers the research and purposes of molecular genetic methods to this crucial affliction, supplying a comprehMolecular Genetics of high blood pressure is among the first books to consolidate the present wisdom of this increasing learn zone.

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For most multifactorial disorders phenotypes are linked to quantitative trait loci (QTLs). 001 for an analysisof variance (ANOVA) definethe threshold of significance. Interested readers in the statistical genetics are encouraged to start with a review by Lander and Schork (1994), followed by Lander andKruglyak (1995)and Elston (1997). 3. Phenotyping The method and protocol used to collect a given phenotype will affect the environmental componentand, therefore, the ability to carry out genetic dissection.

1973) Blood pressure anddietary salt in humanpopulations. Ecol. Food Nutrition 2: 143. , Ying, L. and Moms,B. Clin. Exp. Phmmacol. Physiol. 18: 363-366. , er a&(1997) A mutation causing pseudohypoaldosteronism type 1identifies aconserved glycinethat is involved in the gating of the epithelialsodium channel. EMBOJ. 5: 899-907. , Krause, L. and Schork,N. (1994) Recreational exercise and cardiovascular status in the rural community of Tecumseh, Michigan. Blood Pressure 3: 174-184. , Kotchen, T. and Kotchen,J.

3 Hypenension 13: 5-18. N. (1995) Taking stockof complex trait genetics in mice. R e d in Genetics 1 1 :471-477. , Devynck, M. Nature 284: 282-283. , Baiget, M. and DeLeiva, A. (1997) Molecular diagnosisof von Hippel disease in a kindred with a predominance of familial phaeochromocytoma. Clin. Endocrinol. 46: 359-363. J. Br. J. Pharmucol. 116: 2237-2244. Gleibermann, L. (1973) Blood pressure anddietary salt in humanpopulations. Ecol. Food Nutrition 2: 143. , Ying, L. and Moms,B. Clin. Exp. Phmmacol.

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