By David F. Claxton, Paula Marlton (auth.), Emil J. Freireich M.D., Hagop Kantarjian M.D. (eds.)

Leukemia is a malignant sickness which maintains to play a innovative position within the discovery of recent uncomplicated wisdom in regards to the malignant technique and in regards to the capability for controlling those malignant ailments.
Molecular Genetics and remedy of Leukemia offers contributions by way of prime investigators and clinical individuals to such subject matters as chromosome sixteen, chromosome five, the BCL-2 gene, 11q23 breakpoint leukemias, the p-53 suppressor gene and oncogene, hematopoietic stem cells, cytokines, detection of minimum residual affliction in acute lymphoblastic leukemia, autologous marrow transplantation, the retinoblastoma gene, allogeneic bone marrow transplant and chemotherapy of acute lymphoblastic leukemia.

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Blood 84:3253-3260. 9. Nagarajan L (in press). Molecular analysis of 5q- chromosome. Leukemia Lymphoma. 10. Estey EH, Keating MJ, Dixon DO, Trujillo JM, McCredie KB, Freireich EJ (1987). Karyotype is prognostically more important than the F AB system's distinction between myelodysplastic syndrome and acute myelogenous leukemia. Hematol Pathol 1:203-208. 11. Keating MJ, Cork A, Broach Y, Smith T, Walters RS, McCredie KB, Trujillo J, Freireich EJ (1987). Towards a clinically relevant cytogenetic classification of acute myelogenous leukemia.

Presence of 5qchromosome in RAEB and RAEBT correlates with poorer prognosis than with AMLs with diploid karyotype [10,11]. 5q31 IL4 IL5 IRF1 IL3/GMC5F IL9 05589 EGR1 C014 FGFA GRL C5F1R Figure 1. Consensus map of the genes of human chromosome 5q31. Genes and loci are denoted on the right. IL4, interleukin 4; IL5, interleukin 5; IRF-1, interferon response factor 1; IL3, interleukin 3; GMCSF, granulocyte macrophage colony-stimulating factor; IL9, interleukin 9; D5S89, a polymorphic DNA fragment rearranged in the AML cell line HL60; EGR1, early growth response gene 1; CD14, monocyte antigen; FGF A, acidic fibroblast growth factor; GRL, glucocorticoid receptor; CSF1R, colony stimulating factor 1 receptor.

Nimer SD, Golde DW (1987). The 5q- abnormality. Blood 70:1705-1712. 7. Mecucci C, van den Berghe H (1992). Cytogenetics. HematollOncol Clin North Am 6:523541. 8. Boultwood J, Lewis S, Wainscoat JS (1994). The 5q- syndrome. Blood 84:3253-3260. 9. Nagarajan L (in press). Molecular analysis of 5q- chromosome. Leukemia Lymphoma. 10. Estey EH, Keating MJ, Dixon DO, Trujillo JM, McCredie KB, Freireich EJ (1987). Karyotype is prognostically more important than the F AB system's distinction between myelodysplastic syndrome and acute myelogenous leukemia.

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