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31, 845 (1967). L. Demain, J. Appl Chem. Biotechnol, 22, 345 (1972). J. Haavik, / . Gen. Microbiol, 84, 321 (1974). J. Haavik, ibid, 84, 383 (1974). L. Heyneker et al, Nature, 263, 748 (1976). E. M. Walton, / . , 242, 3239 (1967). F. Martin, Adv. Appl Microbiol, 21, 2 (1977). F. Martin, Microbiology 1976 (ed. D . Schlessinger), p. 548, Am. Soc. , 1977. C M . Liu et al, Antimicrob. , 7, 196 (1975). Z. Janglovâ et al, Folia Microbiol, 14, 208 (1969). L. B. Walker, / . BacterioL, 104, 8 (1970). B.

30, 897-899 (1977). M. Boronin, S. Z. Mindlin, Genetika, 7, 125-131 (1971). A. J. Merrick, Bact. , 41, 595-635 (1977). A. Hopwood, Ann. Rev. MicrobioL, 32, 373-392 (1978). J. Merrick, / . Gen. MicrobioL, 96, 299-315 (1976). F. , 72, 9-28 (1972). H. Okazaki, H. Ono, K. Yamada, T. Beppu and K. Arima, Agric. Biol. , 37, 2319-2325 (1973). H. Okazaki, T. Beppu and K. Arima, ibid, 38, 1455-1461 (1974). 1 Introduction The earth is believed to have been formed about 4,500-4,800 million years ago, when its reductive atmosphere probably consisted of water vapor, ammonia, methane, hydrogen sulfide, hydrogen and carbon dioxide.

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