By Laurent Degos (auth.), Emil J. Freireich, Hagop Kantarjian (eds.)

Leukemia maintains to provide the scientist a distinct chance to realize new wisdom in regards to the malignant transformation. therefore, this multi-authored quantity, dedicated to advances that have happened over the past seven years, presents the reader with a tremendous new realizing of leukemia, yet even perhaps extra very important, predicts analogous, new advancements within the different malignant diagnoses. during this admire, this quantity represents the leading edge of melanoma learn. this article is exclusive in that it contains in one quantity the top participants to their respective fields protecting what the editors consider are the key advances in our wisdom of the biology and treatment of leukemia over the past seven years.

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70] Kraut et al. [68] Ho et al. [71] Total a No. of patients 50 23 33 106 Responses a (%) Complete Partial Minor None 32 20 11 10 1 15 4 4 4 3 63 (59) 26 (25) 9 (8) 8 (8) Responses according to peripheral blood and bone marrow criteria. 24 1 1 At the higher doses used in the early phase I studies, central and peripheral nervous system and renal and hepatic toxicities occurred [73]. With lower doses of DCF, fever, nausea, vomiting, photosensitivity, and keratoconjunctivitis are encountered [8,74].

They were frequently associated with a flulike syndrome of arthralgias and myalgias, often alleviated by acetaminophen. Fever tended to defervesce with recovery of granulocytes. There have been four patients with documented serious 26 infections not related to an infection of a peripherally inserted central venous catheter device used to deliver the 2-CdA. These infections included staphylococcus aureus bacteremia, spontaneous staphylococcal gluteus maximus and thigh abscesses, and a urinary tract infection.

This observation strongly suggests that at least some of the patients in remission still harbor minimal residual leukemic cells with Figure 3-2. PCR amplification of the CDR-III region of the rearranged IgH gene in a pre-B ALL patient: lane M, X174/HaeIII marker; lane 1, pretreatment marrow sample (30 cycles of PCR);Janes 2 and 3, colonigeneic cells from the remission marrow (45 cycles of PCR). 40 proliferative potential. We are following these patients longitudinally to see if they will eventually relapse.

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