By Philip M. Parker

In March 2001, the nationwide Institutes of overall healthiness issued the subsequent caution: "The variety of websites delivering health-related assets grows on a daily basis. Many websites offer worthwhile info, whereas others can have info that's unreliable or misleading." in addition, as a result of the fast raise in Internet-based info, many hours should be wasted looking, making a choice on, and printing. considering that merely the smallest fraction of data facing homocystinuria is listed in se's, corresponding to www.google.com or others, a non-systematic method of net learn will be not just time eating, but additionally incomplete. This booklet was once created for doctors, scholars, and contributors of most people who are looking to behavior scientific examine utilizing the main complex instruments to be had and spending the smallest amount of time doing so.

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Extra resources for Homocystinuria - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers

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Duke University 2424 Erwin Rd. ; Professor; Internal Medicine; University of California Davis Office of Research - Sponsored Programs Davis, Ca 95618 Timing: Fiscal Year 2005; Project Start 01-SEP-2001; Project End 30-APR-2007 Summary: Dietary polyglutamyl folates undergo digestion at the brush border of the intestinal membrane prior to absorption of folic acid derivatives. We characterized the molecular properties of human intestinal folate hydrolase, which is an expression of Glutamate Carboxypeptidase II (GCPII).

9 The advantage of PubMed over previously mentioned sources is that it covers a greater number of domestic and foreign references. It is also free to use. If the publisher has a Web site that offers full text of its journals, PubMed will provide links to that site, as well as to sites offering other related data. User registration, a subscription fee, or some other type of fee may be required to access the full text of articles in some journals. gov/pubmed. Type homocystinuria (or synonyms) into the search box, and click Go.

MEGC-PEG-rMETase had reduced antigenicity compared to rMETase in mice and monkeys indicating the possibility of chronic use of the enzyme to decrease elevated HCY. CBS+/- mice were fed a high-HCY diet containing low levels of folate for 3 months resulting in HCY levels reaching approximately 200 mu M. After treatment with MEGC-PEG-rMETase for one hour, the tHCY levels were depleted to approx 10 mu M, which is in the normal range, thereby demonstrating the proof-of-principle of rMETase as a homocysteine-lowering enzyme.

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