By Report of the Advisory Committee on Health Research
This file is meant to focus on the relevance of genomics (the examine of genomes) for future health care all over the world, with a selected concentrate on its power for bettering healthiness in constructing nations. the applying of data won from the characterization of the genomes of numerous organisms, together with the human genome, holds massive strength for the advance of recent wellbeing and fitness care concepts over the arrival many years. This new box, in spite of the fact that, provides a sequence of hugely advanced medical, monetary, social and moral concerns, which needs to be taken under consideration if the genomic revolution is to profit deprived populations within the constructing nations. during this regard, WHO has a different position to play in aiding its Member States to harvest the entire merits from advances in genomics.
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Additional resources for Genomics and World Health
3 The genomics of disease vectors Progress is also being made towards an understanding of the genomics of vectors for important communicable diseases. , 2002). Extensive studies of the genomes of various strains of mosquitoes are providing information about mechanisms of gene transfer which may lead to the production of new forms with a reduced capacity for disease transmission (Enserink, 2001). 4 The genomes of the worm, fruitfly, yeast and various animals One of the most important tools for identifying coding sequences as well as the regulatory regions of human and pathogen genes is the study of the genomes of other organisms.
By the early 1970s it was estimated that, if no steps were taken to control the disease, in about 40 years time the blood required to treat all the severely affected children would amount to 78,000 units per annum, 40% of the population would have to be blood donors, and the total cost of managing the disease would equal or exceed the Island’s health budget (Weatherall and Clegg, 2001). 2). A great deal is now known about the repertoire of the different kinds of mutations that underlie the molecular pathology of monogenic diseases and how they lead to a disease phenotype.
This method was seminal to advances in human molecular genetics. known as cloning, simply because each derivative from individual colonies contained an identical fragment of DNA. Ingenious methods, based on the observation that DNA or RNA will form stable hybrids with partners which are sufficiently similar in base composition, were developed to identify individual genes of interest. Once isolated, a gene could be sequenced, 30 Genomics and World Health induced to synthesise its products in microorganisms, cultured cells or even in other species, and hence its regulatory regions could be defined.