By E.R. Skinner

Best gurus study the potential position of mind lipids within the improvement of stipulations comparable to schizophrenia, melancholy, Alzheimer's sickness and character issues and violence. a greater knowing of the underlying factors of those debilitating clinical problems is of extreme significance and should give a contribution in the direction of a method of prevention, amelioration and therapy. The e-book is meant to stimulate additional curiosity and bring about elevated study during this very important improvement region.

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1. General Before 1940 it was generally considered that phospholipids, once laid down in the nervous system of mammals during growth and development, were comparatively static entities. However, later studies using (3ZP)orthophosphate showed that brain phospholipids as a whole are metabolically active in vivo (Dawson and Richter 1950, Ansell and Dohmen 1957). In the present study, by following the changes in phospholipid fatty acid 32 Table 3 The turnover of fatty acids in various tissues Fatty acid Half-life (days) DHA EPA Plasma phospholipids 29 18 Erythrocyte phospholipids 21 14 22:5 n-6 Cerebral cortex Phosphatidylethanolamine 21 32 Phosphatidylserine 21 49 Phosphatidylinositol 18 14 Phosphatidylcholine 17 28 composition, we have demonstrated that an n-3 fatty acid-enriched diet can rapidly reverse a severe n-3 fatty acid deficiency in the brains of primates.

An alternative way of releasing HUFAs from the Sn-2 position would be by the sequential action of phospbolipase C to form diacylglycerol and then either PLA2 or DAG lipase to release the HUFA from the Sn-2 position. 2. lbr involvement in reduced HUFA incorporation There are several important candidates. First, in order to be incorporated into phospholipids, fatty acids must be linked to coenzyme A by a fatty acid-CoA ligase (FACL). FACL-4 which is found in the brain and which has high affinity for the HUFAs is one candidate (Horrobin and Bennett 2000).

1 ~' Fed at birth to both the control infants and the n-3 fatty acid prenatal deficient infants. acid deficiency, was only mildly increased in the plasma at birth, the depleted n-3 fatty acids in plasma were mostly substituted by palmitic acid (16:0). After 3 years consuming the soy oil diet, the formerly n-3 fatty acid deficient monkeys showed no signs of the deficiency in the plasma fatty acid composition. 4% vs. 2 (control). To be commented on subsequently was the marked decline in plasma DHA after birth in the control monkeys fed the soy oil diet, which supplied only the precursor fatty acid 18:3 n-3.

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