By Meir Shinitzky
An updated evaluation of easy study on biomembranes. during this quantity, best specialists within the box contemplate an important elements of sign transduction throughout organic membranes: - basic Mechanistic styles of sign Transduction - Receptors for Neurotransmitters and Peptide Hormones - G Proteins in sign Transduction - Membrane-associated Protein Kinases and Phosphatases - Phospholipases in sign Transduction the quantity is a superb complement to 'Biomembranes - actual points' and 'Biomembranes - Structural and useful Aspects', additionally edited by way of Meir Shinitzky. those 3 books jointly offer a complete flooring for realizing advanced physiological techniques. Meir Shinitzky, Ph. D., is Professor of Biophysics within the division of Membrane study and Biophysics, The Weizman Institute of technology, Rehovot, Israel. due to the fact 1971, his learn has occupied with quite a few features of membrane constitution and dynamics.
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Extra info for Biomembranes, Singal Transduction Across Membranes
Sigual transduction pathways involved in Drosophila eye and C. elegans vulva development. T h e product of the genes, identified by genetic loss- or gain-of-function mutation analysis, involved in the signal transduction of either Drosophila eye development (a) or C’. elegans vulvadevelopment @) are represented. In the middle their function is indicated based on homology to their mammalian counterparts (see text for more details). importance of the let-23 gene, encoding a receptor tyrosine kinase with similarity to the EGF-R, in proper vulva1 development.
The enzyme AC is a main effector enzyme for many G-proteincoupled receptors (see Fig. 4) but can also be activated by several growth factor receptors containing tyrosine kinase activity, as well as by several cytokine receptors . The enzyme can be modeled as an integral membrane protein, having two hydrophobic domains which each contain six membrane-spanning domains, and two hydrophilic cytoplasmic domains. Its activation results in the conversion of ATP into cAMP which in turn can play a role as a second messenger, for example in the activation of PKA [ 1321.
This class of receptors is mainly characterized by the presence of a conserved group of four cysteine residues, a juxtamembrane conserved box including the sequence TrpSer-X-Trp-Ser ( W S X W S ) and a fibronectin 3 homologous motif, and the presence of immunoglobulin-like domains. Further subclassification of this class of receptors is possible based on the variations of these structures. The first subclass includes the 11-1-R, which has three immunoglobulin-like loops only. The second subclass includes the G-CSF-R and 11-6-R /3-chain (also known as gp130), all of which have the three characteristics once.