Content:
Chapter 1 advent (pages 1–4): G. V. R. Born
Chapter 2 universal Pathways of Membrane Reactivity after Stimulation of Platelets via varied brokers (pages 5–21): Ernst F. Luscher and P. Massini
Chapter three Binding of Adenosine Diphosphate by means of Human Platelet Membrane (pages 23–46): Ralph L. Nachman
Chapter four Enzyme actions at the Platelet floor with regards to the motion of Adenosine Diphosphate (pages 47–75): J. Fraser Mustard, M. A. Packham, D. W. Perry, M. A. Guccione and R. L. Kinlough?Rathbone
Chapter five Stimulus?Response Coupling within the Thrombin?Platelet interplay (pages 77–100): Thomas C. Detwiler, Bernice M. Martin and Richard D. Feinman
Chapter 6 The interplay of Platelet Actin, Myosin and Myosin mild Chain Kinase (pages 101–119): Robert S. Adelstein, Mary Anne Conti, James L. Daniel and William Anderson
Chapter 7 Roles of Cyclic Nucleotides in Platelet functionality (pages 121–151): Richard J. Haslam
Chapter eight preliminary Biochemical Responses of Platelets to Stimulation (pages 153–173): D. C. B. Mills
Chapter nine Biochemistry of the Platelet unlock response (pages 175–205): Holm Holmsen
Chapter 10 Prostaglandins and Precursors in Platelet functionality (pages 207–224): J. Bryan Smith, Carol M. Ingerman and Melvin J. Silver
Chapter eleven importance of Glucose and Glycogen Metabolism for Platelet functionality (pages 225–238): W. Schneider and A. R. L. Gear
Chapter 12 Elemental Composition of Platelet Dense our bodies (pages 239–259): R. J. Skaer
Chapter thirteen The Organelles Storing 5?Hydroxytryptamine in Blood Platelets (pages 261–286): A. Pletscher and M. Da Prada
Chapter 14 5?Hydroxytryptamine Receptors of Platelets (pages 287–307): G. V. R. Born and F. Michal
Chapter 15 Interactions among 5?Hydroxytryptamine and Platelet Lipid Fractions (pages 309–342): Aaron J. Marcus, Lenore B. Safier and Harris L. Ullman

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Additional resources for Ciba Foundation Symposium 35 - Biochemistry and Pharmacology of Platelets

Example text

When one is studying the pharmacology of the uptake of 5HT by whole platelets, considerable information can be obtained about receptor mechanisms. On the other hand, when one is studying an isolated platelet fraction with the potential of binding ADP or 5HT, the term ‘receptor’ may not be entirely accurate. Perhaps the term ‘acceptor’ would be bettei. In other tissues it has been possible to obtain 44 DISCUSSION subcellular particles-in the form of either membranes or soluble fractionswhich take up hormones in a reversible manner, and it has beeii possible to study kinetics and other properties of the uptake.

We didn’t measure the enzyme in the soluble receptor preparation. Mustard: If [14C]ADPis added to the supernatant from a platelet suspension, it is not converted to [14C]ATP unless a source of phosphoryl donor in the form of ATP or another nucleoside triphosphate is added (Guccione et al. 1971). One cannot exclude the possibility that nucleosidediphosphate kinase was present in the preparations unless one does an experiment of this sort. Nachman: We did that assay with the membrane particles, and there was no conversion of labelled ADP to ATP.

These findings strongly suggest that the molecule recognized by this antibody is absent from, or structurally modified in, thrombasthenic patients, and that it may be involved in platelet aggregation. Nuchmun: Is this a surface antigen'? Cum: It seems to be. Nuchmun: Do you have any kinetic studies on the relative affinity of the receptor for ADP? Cuen: Not yet. References BORN,G. V. R . (1965) Uptake of adenosine and of adenosine diphosphate by human blood platelets. ) 206, 1121-1122 BURGEN, A.

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