By Michelle M. Le Beau, Janet D. Rowley (auth.), Harry Harris, Kurt Hirschhorn (eds.)

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The other chromosome involved in these complex rearrangements is variable. For each type of leukemia, the rearranged chromosome that is consistently involved in both the simple and complex translocations is enclosed in a box. ] Chromosomal Localization of Cellular Oncogenes One of the most exciting revelations in the past year has involved the cellular oncogenes and their chromosomal location. Much of the excitement derives from the observation that many oncogenes are located in the bands that are involved in consistent translocations (Rowley, 1983c; Human Gene Mapping 7, 1984) (Fig.

Only five of 163 ANLL patients whom we have studied had increased numbers of marrow basophils ( > 1%) in the absence of t(6;9). Of the nine t(6;9) patients, five were classified as AML-M2, three as AMMoL-M4, and one as AML-Ml. The median age was 38 years, which is lower than that of other ANLL patients. As a group, patients with a t(6;9) have responded poorly to intensive remission induction therapy. Of all reported cases, only two of 11 (27%) treated patients had a complete remission. This finding contrasts with that noted at the Fourth Workshop, in which 57% of intensively treated patients had a CR.

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