By Jeffrey C. Hall

The sector of genetics is speedily evolving and new clinical breakthroughs are occuring due to advances in wisdom won from genetics study. This sequence continuously publishes very important stories of the broadest curiosity to geneticists and their colleagues in affiliated disciplines.

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Petryshen, T. , et al. (2004). Assessing the impact of population stratification on genetic association studies. Nat. Genet. 36, 388–393. , Hein, D. , et al. (2005). NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: Results from the Spanish Bladder Cancer Study and meta-analyses. Lancet 366, 649–659. , Nibbs, R. , Freedman, B. , Quinones, M. , Bamshad, M. , Murthy, K. , Rovin, B. , et al. (2005). The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.

Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science 277, 959–965. , Cooper, J. , Collins, J. , Heward, J. , Franklyn, J. , Howson, J. , Rance, H. , Barratt, B. , et al. (2004). Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 53, 3020–3023.

2004). Detection of large-scale variation in the human genome. Nat. Genet. 36, 949–951. International HapMap Consortium (2005). A haplotype map of the human genome. Nature 437, 1299–1320. International Human Genome Sequencing Consortium (2004). Finishing the euchromatic sequence of the human genome. Nature 431, 931–945. Ioannidis, J. , Higgins, J. , Bernstein, J. , Bray, M. , Brenchley, P. , Buffler, P. , Casas, J. , et al. (2006). A road map for efficient and reliable human genome epidemiology.

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